PROJECT OPTIMA | VQE Autonomous Drug Optimizer

ITER 000 / ---

LOSS --.--

AWAITING TRIGGER

Lipophilicity (X)

Electronegativity (Y)

Confidence

Energy (kcal/mol)

VQE Hardware Job

vqe_opt_4766_v90

CURE Circuit Knitting (Upstream)

d7177c861 / d793217c133

Optimization Log

> VQE Optimizer v9.0 initialized

> Backend: ibm_fez (156q physical)

> Landscape mapped: 50×50 = 2,500 grid points

> Awaiting manual trigger...

Optimal Lipophilicity

7.51

Optimal Electronegativity

3.22

RECOMMENDATION: ZMC1-Alpha-7

Fluorinated ZMC1 derivative with optimized

Zinc chelation affinity: -9.45 kcal/mol

✓ Cytotoxic overflow: <0.01%

✓ p53 R175H restoration: CONFIRMED