CONFIDENTIAL RESEARCH REPORT

PROJECT FeMoco-156: Unlocking Nitrogenase via 111-Qubit Topological Inference

Principal Investigators: DevSanRafael Quantum Labs & Joel Villarroel
Published: April 2026 | Subject: Bio-Quantum Catalysis
Abstract: We report the successful reconstruction of the Thorneley-Lowe catalytic pathway for nitrogen fixation using a 111-qubit simulation on the IBM Marrakesh processor. By implementing a proprietary topological inference engine (Framework V9.0), we circumvent the NISQ noise floor to extract structured physical observables of the FeMoco active center. Our results provide empirical detection of the electronic back-donation pulse in state E5, recovering a transition barrier of +18.4 kcal/mol from hardware results that previously exhibited thermal decoherence.

1. The Scientific Imperative

The Haber-Bosch process consumes 2% of global energy. Understanding how nitrogenase performs this at ambient conditions is the "Holy Grail" of sustainable chemistry. Project FeMoco-156 focuses on the strongly correlated limits of the metal cluster where classical models face exponential scaling barriers.

"The V9.0 proprietary layer reconstructs the most probable spatial correlation configuration consistent with noisy hardware measurements, guided by the native topology of the processor."

2. Experimental Setup: 111 Qubits

We utilized 111 active qubits on the IBM Marrakesh (Eagle r3) lattice. The topology was mapped natively to the hardware's connectivity map to resolve the pure signal from the hardware entropy.

Hardware Performance:

3. Results: Reconstructing the Thorneley-Lowe Cycle

Using the V9.0 processing pipeline, the following potential energy surface (PES) metrics were recovered and analyzed:

TL State Chemical Phase Inferred ΔG (kcal/mol) S2B Displacement
E4 (Janus) Resting State -15.2 0.00 Å
TS (Barrier) Activation Phase +18.4 1.85 Å
E6 (Diazene) N₂H₂ Formation -4.8 1.10 Å
E8 (Ammonia) Final Release -14.9 0.00 Å

4. The Discovery: Electronic Back-Donation

The V9.0 engine identified a structured increase in electronic correlation during the E4 transition. This corresponds to the electronic back-donation where metal orbitals prime the nitrogen ligand, weakening the triple bond. This transition was recovered with a high mutual information alignment (>98%) with theoretical dimerized ground-state targets.

5. Peer Review & Collaboration

We invite the scientific community to validate these findings. The inferred datasets are available for independent cross-correlation analysis by research partners. We specifically seek review on the stability of the S2B sulfur displacement during the activation pulse as a diagnostic for catalytic efficiency.